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KMID : 1189420070200010051
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 1 p.51 ~ p.65
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Effects of Sophorae Flos on Steptozotocin-induced Diabetic Mellitus in Rats
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Kim Hyun-Ji
Kim Kyung-Jun
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Abstract
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Objective: The present study was carried out to investigate the preventive effect of Sophorae Flos on streptozotocin - induced Diabetes mellitus.
Method: Sophorae Flos was given to rats with oral administration. The experimental animals were divided into 3groups : normal group of rats, control group of Streptozotocin-induced diabetic rats, sample group with Sophorae Flos . The effect of Sophorae Flos on Streptozotocin-induced diabetes was observed by measuring the survival rate of rats, weight of rats, FER, blood glucose, each organ weight of rat, total cholesterol, HDL, GOT, GPT & creatinine.
Result: Streptozotocin caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic . Sophorae Flos treatment don’t protected them from hyperglycemia and hypoinsulinemia. Organ weight liver, kidney, heart & spleen shows no significant changes. Sophorae Flos significantly don’t recoverd the increase of several biochemical parameters such as blood glucose, total cholesterol, HDL, GOT, GPT, antioxidant & creatinine is vice versa.
Conclusion: Sophorae Flos extract group did not show significant decrease than Streptozotocin control group.
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KEYWORD
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SophoraeFlos, DiabetesMellitus, Streptozotocin
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